The aim of this study was to investigate the molecular profile of α-thalassemia variants and to compare and characterise the chromatographic behaviour and haematological properties of α-thalassemia minor (-α/-α, -/ααα) and α-silent carriers (-α/ααα) on HPLC.Ī dataset of 200 individuals consisting of 42 alpha thalassemia minor (-α/-α, - /ααα), 103 alpha silent carriers (-α/αα) and 55 normal participants from the Human Genetics Unit (HGU) of the Faculty of Medicine, Colombo, Srilanka was included.
Alpha-thalassaemia is a group of disorders characterised by wide phenotypic variation caused by mutations in the α-globin genes (α1 and α2) of chromosome 16.
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